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Bethanechol chloride

Name: Bethanechol chloride
Brand: TargetMol
SKU: T3126
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3126Cas No. 590-63-6

Alias Urecholine, Myocholine, Carbamyl-β-methylcholine chloride, (±)-Bethanechol

Bethanechol chloride (Carbamyl-β-methylcholine chloride) is a slowly hydrolyzing muscarinic agonist with no nicotinic effects. It is used to increase smooth muscle tone in the GI tract following abdominal surgery or to treat urinary retention without obstruction. Possible side effects include hypotension, heart rate changes, and bronchial spasm.

Bethanechol chloride

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Purity: 99.73%

Catalog No. T3126Alias Urecholine, Myocholine, Carbamyl-β-methylcholine chloride, (±)-BethanecholCas No. 590-63-6

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$30	-	In Stock
1 g	$37	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.73%

Color:White

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COA HNMR LCMS

Product Introduction

Bethanechol chloride AI Summary

Bethanechol chloride exhibits agonist activity at muscarinic receptors M2, M3, and M4 in guinea pig tissues, with specific potency (pD2 values) of 5.59, 6.26, and 4.68 respectively. It also shows inhibition of electrically-stimulated muscle contraction with pD2 values of 5.01, 6.16, and 5.88 for M2, M3, and M4 receptors, respectively. The compound has intrinsic activity of 1.0 at these muscarinic receptors relative to McN-A-343. Additionally, Bethanechol chloride inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells with inhibition percentages of 111.12% and 100.03% respectively at a concentration of 10 µM, indicating strong bioactivity in blocking the uptake of sodium fluorescein. It also exhibits multiple bioactivities such as inhibiting Tau fibril formation, G9a histone lysine methyltransferase, and ERG Ets/DNA interaction. Furthermore, it induces DNA re-replication in both normal breast and colon adenocarcinoma cells and shows differential inhibition of Plasmodium falciparum proliferation, leading to delayed death of the malarial parasite plastid. The compound exhibits minimal antiviral activity in Vero E6 cells against SARS-CoV-2 after 72 hours (inhibition index 0.1188) and modest activity in inhibiting SARS-CoV-2 3CL-Pro protease (3.916% at 20 µM). Additionally, it demonstrates 35.01% inhibition of SARS-CoV-2-induced cytotoxicity in Caco-2 cells at a concentration of 10 µM after 48 hours. It also has low antifungal activity against Candida albicans and Cryptococcus neoformans, while exhibiting variable antibacterial activity against several bacterial strains, including Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus aureus MRSA..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Bethanechol chloride (Carbamyl-β-methylcholine chloride) is a slowly hydrolyzing muscarinic agonist with no nicotinic effects. It is used to increase smooth muscle tone in the GI tract following abdominal surgery or to treat urinary retention without obstruction. Possible side effects include hypotension, heart rate changes, and bronchial spasm.
Synonyms	Urecholine, Myocholine, Carbamyl-β-methylcholine chloride, (±)-Bethanechol

Chemical Properties

Molecular Weight	196.68
Formula	C₇H₁₇N₂O₂·Cl
Cas No.	590-63-6
Smiles	[Cl-].O(C(C[N+](C)(C)C)C)C(=O)N
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 36 mg/mL (183.04 mM), Sonication is recommended.

DMSO: 37 mg/mL (188.12 mM), Sonication is recommended.

Ethanol: 37 mg/mL (188.12 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	5.0844 mL	25.4220 mL	50.8440 mL	254.2201 mL
5 mM	1.0169 mL	5.0844 mL	10.1688 mL	50.8440 mL
10 mM	0.5084 mL	2.5422 mL	5.0844 mL	25.4220 mL
20 mM	0.2542 mL	1.2711 mL	2.5422 mL	12.7110 mL
50 mM	0.1017 mL	0.5084 mL	1.0169 mL	5.0844 mL
100 mM	0.0508 mL	0.2542 mL	0.5084 mL	2.5422 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc